Development and Validation of a Clinically Relevant Workflow for MR-Guided Volumetric Arc Therapy in a Rabbit Model of Head and Neck Cancer

Cancers

AnuragK. Singh¹  JosephA. Spernyak²  Harish Malhotra²  Leslie Curtin³  Sandra Sexton³  LaurieJ. Rich⁴  Eftekhar Rajab Bolookat⁴  Mukund Seshadri⁴ 

[1] Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;Department of Radiology—Medical Physics Program, University at Buffalo—Jacobs School of Medicine and Biomedical Sciences, 955 Main Street, Buffalo, NY 14203, USA;Laboratory Animal Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;Laboratory for Translational Imaging, Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;

关键词: image-guided radiation therapy;    vmat;    mri;    hnscc;   

DOI  :  10.3390/cancers12030572

来源: DOAJ

【 摘 要 】

There is increased interest in the use of magnetic resonance imaging (MRI) for guiding radiation therapy (RT) in the clinical setting. In this regard, preclinical studies can play an important role in understanding the added value of MRI in RT planning. In the present study, we developed and validated a clinically relevant integrated workflow for MRI-guided volumetric arc therapy (VMAT) in a VX2 rabbit neck tumor model of HNSCC. In addition to demonstrating safety and feasibility, we examined the therapeutic impact of MR-guided VMAT using a single high dose to obtain proof-of-concept and compared the response to conventional 2D-RT. Contrast-enhanced MRI (CE-MRI) provided excellent soft tissue contrast for accurate tumor segmentation for VMAT. Notably, MRI-guided RT enabled improved tumor targeting ability and minimal dose to organs at risk (OAR) compared to 2D-RT, which resulted in notable morbidity within a few weeks of RT. Our results highlight the value of integrating MRI into the workflow for VMAT for improved delineation of tumor anatomy and optimal treatment planning. The model combined with the multimodal imaging approach can serve as a valuable platform for the conduct of preclinical RT trials.

【 授权许可】

Unknown