A Novel SEC22B-NOTCH2 Fusion in Chronic Lymphocytic Leukemia

Human Pathology: Case Reports

Dora Dias-Santagata¹  Valentina Nardi²  Jon C. Aster³  Rory Crotty³ 

[1] Corresponding author at: Massachusetts General Hospital and Harvard Medical School, Department of Pathology, Warren Building 225, 55 Fruit Street, Boston, MA 02114, United States.;Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States;Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;

关键词: Chronic lymphocytic leukemia;    Molecular alteration;    Gene rearrangement;    Gamma-secretase inhibitors;    Breast carcinoma;   

DOI  :  

来源: DOAJ

【 摘 要 】

Chronic lymphocytic leukemia (CLL) is a neoplasm composed of monoclonal mature B lymphocytes. It demonstrates a heterogenous genomic landscape, commonly associated with karyotypic abnormalities. Here we report a case of CLL that demonstrated a rearrangement of the NOTCH2 gene with SEC22B, forming a novel fusion not previously reported in CLL.

【 授权许可】

Unknown