Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties

Nanomaterials

Pooria Mostafalu¹  Ali Tamayol¹  Kamyar Mollazadeh Moghaddam¹  Mohamadmahdi Samandari¹  Nasim Annabi¹  Musab Aldhahri²  Mohamed Shaaban Abdel-wahab²  Ali Khademhosseini²  Adnan Memic²  Sidi A. Bencherif³ 

[1] Biomaterials Innovation Research Center (BIRC), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA;Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia;Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA;

关键词: electrospinning;    electrical properties;    nanocoatings;    flexible electronics;   

DOI  :  10.3390/nano7030063

来源: DOAJ

【 摘 要 】

Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications.

【 授权许可】

Unknown