Automatic Aortic Valve Cusps Segmentation from CT Images Based on the Cascading Multiple Deep Neural Networks

Journal of Imaging

Xiao Xue¹  Longfei Zhao¹  Shun Zhao¹  Yunxin Zhong¹  Gakuto Aoyama²  Takuya Sakaguchi²  Naoki Tomii³  Shu Takagi³  Ichiro Sakuma³  Minoru Ono⁴  Eriko Maeda⁴  Hiroyuki Tsukihara⁴  Kenji Ino⁴  Haruo Yamauchi⁴ 

[1] Research and Development Center, Canon Medical Systems (CHINA) CO., LTD., Chao Yang District, Beijing 100015, China;Research and Development Center, Canon Medical Systems Corporation, 1385 Shimoishigami, Otawara 324-8550, Japan;School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan;The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan;

关键词: segmentation;    seep learning;    computed tomography;    aortic valve;   

DOI  :  10.3390/jimaging8010011

来源: DOAJ

【 摘 要 】

Accurate morphological information on aortic valve cusps is critical in treatment planning. Image segmentation is necessary to acquire this information, but manual segmentation is tedious and time consuming. In this paper, we propose a fully automatic aortic valve cusps segmentation method from CT images by combining two deep neural networks, spatial configuration-Net for detecting anatomical landmarks and U-Net for segmentation of aortic valve components. A total of 258 CT volumes of end systolic and end diastolic phases, which include cases with and without severe calcifications, were collected and manually annotated for each aortic valve component. The collected CT volumes were split 6:2:2 for the training, validation and test steps, and our method was evaluated by five-fold cross validation. The segmentation was successful for all CT volumes with 69.26 s as mean processing time. For the segmentation results of the aortic root, the right-coronary cusp, the left-coronary cusp and the non-coronary cusp, mean Dice Coefficient were 0.95, 0.70, 0.69, and 0.67, respectively. There were strong correlations between measurement values automatically calculated based on the annotations and those based on the segmentation results. The results suggest that our method can be used to automatically obtain measurement values for aortic valve morphology.

【 授权许可】

Unknown