The Experience of a Novel Glycylcycline Antibiotic for a Patient with Infection Caused by Multiple Drug-Resistant Pathogens: What is the Benefit?

International Journal of Gerontology

Shih-Yi Lee¹  Po-Chin Chi¹  Ching-Chi Lin¹  Yu-Ling Weng¹  Chung-Lieh Hung¹  Chien-Liang Wu¹ 

[1] Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan;

关键词: multiple antibacterial drug resistance;    tigecycline;    ventilator-associated pneumonia;   

DOI  :  10.1016/S1873-9598(08)70050-4

来源: DOAJ

【 摘 要 】

We report a 75-year-old man with septic shock induced by ventilator-associated pneumonia caused by multiple drug-resistant Acinetobacter baumannii and catheter-related infection by vancomycin-resistant enterococci. He failed to respond to the initial management, including antibiotics (linezolid, imipenem, sulbactam and colistin) and hemodynamic-guided fluid challenge. However, his condition improved dramatically after the antibiotic regimen was changed to tigecycline and ceftazidime. In addition to the superiority of the antibacterial effect of tigecycline, fluid control can be achieved more easily while using a single antibiotic instead of multiple drugs, which is also important for care of a critically ill elderly man with compromised cardiorespiratory or renal function. Here, we present a patient infected with multiple drug-resistant pathogens, who improved clinically after being treated with tigecycline, to demonstrate the benefits of this antibiotic.

【 授权许可】

Unknown