Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease

Cells

Lubos Ambro¹  Rene Link¹  Roman Gardlik²  Martin Maronek² 

[1] Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, 040 11 Košice, Slovakia;Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia;

关键词: virome;    phageome;    inflammatory bowel disease;    intestinal inflammation;    phage therapy;   

DOI  :  10.3390/cells9041013

来源: DOAJ

【 摘 要 】

Inflammatory bowel diseases (IBDs) are a group of chronic autoinflammatory diseases including Crohn’s disease and ulcerative colitis. Although the molecular mechanisms governing the pathogenesis of gastrointestinal inflammation are not completely clear, the main factors are presumed to be genetic predisposition, environmental exposure, and the intestinal microbiome. Hitherto, most of the studies focusing on the role of the microbiome studied the action and effect of bacteria. However, the intestinal microbiome comprises other members of the microbial community as well, namely, fungi, protozoa, and viruses. We believe that bacteriophages are among the main orchestrators of the effect of microbiota on the gut mucosa. Therefore, this review aims to summarize the knowledge of the role of intestinal phageome in IBD and to discuss the concept of phage therapy and its future applications.

【 授权许可】

Unknown