Research Progress on the Role and Mechanism of Action of Activin A in Brain Injury

Frontiers in Neuroscience

Lingyi Huang²  Dezhi Mu³  Yi Qu³  Xiaojuan Su³  Dongqiong Xiao³ 

[1] Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China;Department of Stomatology, West China College of Stomatology, Sichuan University, Chengdu, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China;

关键词: activin A;    transforming growth factor β;    activin A/Smad;    brain injury;    neuroprotection;    target therapy;   

DOI  :  10.3389/fnins.2018.00697

来源: DOAJ

【 摘 要 】

Activin A belongs to the transforming growth factor superfamily and has a variety of biological functions. Studies have revealed that activin A can regulate the body's immune and inflammatory responses and participate in the regulation of cell death. In addition, activin A also has neurotrophic function and plays an important role in the repair of brain damage. This article summarizes recent advances in understanding the role and mechanism of action of activin A in brain injury and provides new hints into the application of activin A in the treatment of brain injury.

【 授权许可】

Unknown