The free energy landscape of retroviral integration

Nature Communications

Lukas F. Milles¹  Philipp U. Walker¹  Pauline J. Kolbeck¹  Jan Lipfert¹  Willem Vanderlinden¹  Philipp C. Nickels¹  Wolfgang Ott¹  Zeger Debyser²  Tine Brouns³ 

[1]Department of Physics, Nanosystems Initiative Munich, Center for NanoScience, LMU Munich

[2]KU Leuven, Department of Pharmaceutical and Pharmacological Sciences

[3]KU Leuven, Division of Molecular Imaging and Photonics

DOI  :  10.1038/s41467-019-12649-w

来源: DOAJ

【 摘 要 】

Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasingly stable, resulting in a net forward rate.

【 授权许可】

Unknown