Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.

Gut Microbes

Marlene B. Lauritsen¹  Mette Nyegaard²  Caspar Bundgaard-Nielsen³  Søren Hagstrøm³  Suzette Sørensen³  Peter D. C. Leutscher³  Julie Knudsen³ 

[1] Aalborg University Hospital;Aarhus University;Centre for Clinical Research, North Denmark Regional Hospital;

关键词: autism spectrum disorder;    attention-deficit hyperactivity disorder;    neurodevelopmental disorders;    microbiota;    microbiome;    systematic review;    gut-brain axis;   

DOI  :  10.1080/19490976.2020.1748258

来源: DOAJ

【 摘 要 】

Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders. Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed. Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies.

【 授权许可】

Unknown