Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis

Frontiers in Oncology

Ruud Houben¹  Marc Vooijs²  Eloy Moreno Roig²  Ludwig Dubois²  Ala Yaromina²  Arjan J. Groot² 

[1] Department of Radiation Oncology, MAASTRO Clinic, Maastricht, Netherlands;Department of Radiotherapy (MAASTRO)/GROW – School for Developmental Biology and Oncology, Maastricht University, Maastricht, Netherlands;

关键词: cancer;    hypoxia-inducible factor-2;    meta-analysis;    prognosis;    endothelial PAS domain protein-1;   

DOI  :  10.3389/fonc.2018.00224

来源: DOAJ

【 摘 要 】

Hypoxia-inducible factor-2α (HIF-2α) plays an important role in tumor progression and metastasis. A number of studies have evaluated the correlation between HIF-2α overexpression and clinical outcome in cancer patients but yielded inconsistent results. To comprehensively and quantitatively summarize the evidence on the capability of HIF-2α to predict the prognosis of cancer patients with solid tumors, a meta-analysis was carried out. Renal cell carcinoma (CC-RCC) was separately analyzed due to an alternative mechanism of regulation. Systematic literature searches were performed in PubMed and Embase databases for relevant original articles until February 2018. Forty-nine studies with 6,052 patients were included in this study. The pooled hazard ratios (HRs) with corresponding confidence intervals were calculated to assess the prognostic value of HIF-2α protein expression in tumor cells. The meta-analysis revealed strong significant negative associations between HIF-2α expression and five endpoints: overall survival [HR = 1.69, 95% confidence interval (95% CI) 1.39–2.06], disease-free survival (HR = 1.87, 95% CI 1.2–2.92), disease-specific survival (HR = 1.57, 95% CI 1.06–2.34), metastasis-free survival (HR = 2.67, 95% CI 1.32–5.38), and progression-free survival (HR = 2.18, 95% CI 1.25–3.78). Subgroup analyses revealed similar associations in the majority of tumor sites. Overall, these data demonstrate a negative prognostic role of HIF-2α in patients suffering from different types of solid tumors.

【 授权许可】

Unknown