Plasma Sphingolipids in Acute Pancreatitis

International Journal of Molecular Sciences

Lucyna Ostrowska¹  Andrzej Dąbrowski²  Krzysztof Kurek²  Małgorzata Żendzian-Piotrowska³  Tomasz Konończuk³  Michalina Krzyżak³  Bartłomiej Łukaszuk⁴ 

[1] Department of Clinical Nutrition, Medical University of Białystok, Mieszka I 4b Street, 15-054 Bialystok, Poland;Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, Skłodowskiej MC 24a Street, 15-276 Bialystok, Poland;Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Mickiewicza 2c Street, 15-022 Bialystok, Poland;Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Street, 15-222 Bialystok, Poland;

关键词: sphingolipids;    acute pancreatitis;    ceramide;    sphingosine;    sphingosine-1-phosphate;   

DOI  :  10.3390/ijms18122606

来源: DOAJ

【 摘 要 】

Acute pancreatitis (AP) is a prevalent gastrointestinal disorder associated with systemic inflammatory response syndrome and, in the case of severe AP, a mortality rate ranging from 36% to 50%. Standard clinical treatment of AP includes intensive hydration, analgesia, and management of complications. Unfortunately, the direct treatment of AP at the level of its molecular pathomechanism has not yet been established. Recent studies indicate that the sphingolipid signaling pathway may be one of the important factors contributing to the development of inflammation in pancreatic diseases. In the current study, we sought to investigate this promising route. We examined the plasma sphingolipid profile of 44 patients with acute pancreatitis, dividing them into three groups: mild, moderate and severe AP. Samples were collected from these groups at days 1, 3 and 7 following their hospital admission. We demonstrated significant changes in blood plasma sphingolipids in relation to the time course of AP. We also found an inhibition of de novo ceramide synthesis in mild and moderate AP. However, the most important and novel finding was a significant elevation in sphingosine-1-phosphate (S1P) (a downstream metabolite of ceramide) in mild AP, as well as a dramatic reduction in the lipid molecule content in the early stage (days 1 and 3) of severe AP. This strongly indicates that plasma S1P could serve as a prognostic marker of AP severity.

【 授权许可】

Unknown