Bromodomain AAA+ ATPases get into shape

Nucleus

Magdalena Murawska¹  Andreas G. Ladurner¹ 

[1] Ludwig-Maximilians-University of Munich;

关键词: abo1;    bromodomain aaa+ atpase;    histone chaperone;   

DOI  :  10.1080/19491034.2020.1741304

来源: DOAJ

【 摘 要 】

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

【 授权许可】

Unknown