期刊论文详细信息
Cancers
Quality of Automated Stereotactic Radiosurgery Plans in Patients with 4 to 10 Brain Metastases
Mireille Florijn1  Anna Petoukhova1  Roland Snijder1  Rudolf Wiggenraad2  Ivonne Mudde-van der Wouden2  Linda de Boer-de Wit2  Jaap Zindler2 
[1] Department of Medical Physics, Haaglanden Medical Center, 2262 BA Leidschendam, The Netherlands;Department of Radiation Oncology, Haaglanden Medical Center, 2262 BA Leidschendam, The Netherlands;
关键词: multiple brain metastases;    linac-based stereotactic radiosurgery or hypofractionated stereotactic radiotherapy;    automated planning;    single isocenter;    IMRT;    DCA;   
DOI  :  10.3390/cancers13143458
来源: DOAJ
【 摘 要 】

The purpose was to compare linac-based stereotactic radiosurgery and hypofractionated radiotherapy plan quality of automated planning, intensity modulated radiotherapy (IMRT) and manual dynamic conformal arc (DCA) plans as well as single- and multiple-isocenter techniques for multiple brain metastases (BM). For twelve patients with four to ten BM, seven non-coplanar linac-based plans were created: a manually planned DCA plan with a separate isocenter for each metastasis, a single-isocenter dynamic IMRT plan, an automatically generated single-isocenter volumetric modulated arc radiotherapy (VMAT) plan, four automatically generated single-isocenter DCA plans with three or five couch angles, with high or low sparing of normal tissue. Paddick conformity index, gradient index (GI), mean dose, total V12Gy and V5Gy of uninvolved brain, number of monitor units (MUs), irradiation time and pass rate were compared. The GI was significantly higher for VMAT than for separate-isocenter, IMRT, and all automatically generated plans. The number of MUs was lowest for VMAT, followed by automatically generated DCA and IMRT plans and highest for manual DCA plans. Irradiation time was the shortest for automatically planned DCA plans. Automatically generated linac-based single-isocenter plans for multiple BM reduce the number of MUs and irradiation time with at least comparable GI and V5Gy relative to the reference separate-isocenter DCA plans.

【 授权许可】

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