Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Journal of Biomedical Science

Takashi Angata¹ 

[1] Institute of Biological Chemistry, Academia Sinica;

关键词: Siglec-15;    Sialic acid;    Osteoclast;    Macrophage;    Cancer;    Microbial infection;   

DOI  :  10.1186/s12929-019-0610-1

来源: DOAJ

【 摘 要 】

Abstract Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration.

【 授权许可】

Unknown