Chronic low back pain, Modic changes and low-grade virulent infection: efficacy of antibiotic treatment

Future Science OA

Gerard M Hall¹  Claus Manniche² 

[1] Environmental Medicine, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark;;1Department of Occupational &

关键词: antibiotics;    Cutibacterium acnes;    disc;    infection;    low back pain;    Modic changes;   

DOI  :  10.2144/fsoa-2021-0026

来源: DOAJ

【 摘 要 】

Chronic low back pain (CLBP) has consistently been associated with the longest number of years lived with a disability in global studies, while commonly used treatments for CLBP are largely ineffective. In 2013 a randomized, double-blind, controlled study demonstrated significant improvements in CLBP patients demonstrating Modic changes type 1 on their MRI scans and undergoing long-term oral antibiotic treatment (100 days). Much of the ensuing debate has focused on whether this was a true infection or contamination. Newer and more advanced technologies clearly point to an ongoing low-grade infection. We have reviewed all of the clinical trials published in the recent past and conclude that there is compelling evidence for the effect of long-term oral antibiotic treatment for this patient group.

【 授权许可】

Unknown