Cognitive dysfunction in Nigerian women with epilepsy on carbamazepine and levetiracetam monotherapy

Brain and Behavior

Bamidele Osalusi¹  Akintomiwa Makanjuola²  Joseph Yaria²  Adesola Ogunniyi²  Adeyinka Aderinola³  Akinyinka Alabi³  Luqman Ogunjimi³  David Oboh⁴  Mojisola Olusola‐Bello⁵ 

[1] Department of Medicine Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University Sagamu Nigeria;Department of Medicine University College Hospital Ibadan Nigeria;Department of Pharmacology and Therapeutics Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University Sagamu Nigeria;Department of Radiology University College Hospital Ibadan Nigeria;Radiology Department Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University Sagamu Nigeria;

关键词: cognition;    epilepsy;    women;   

DOI  :  10.1002/brb3.2038

来源: DOAJ

【 摘 要 】

Abstract Background This study aims to identify the determinants of cognitive dysfunction and compare the effect of CPZ and LTC on cognition in WWE. Methods An observational study involving 87 consenting adult WWE aged between 16 and 40 years on LTC or CZP monotherapy. At enrollment, an interviewer‐based questionnaire was used to obtain demographic and clinical information from participants. The diagnosis of epilepsy was mainly clinical and supported by electroencephalographic (EEG) features and classified based on recommendation by the 2017 International League Against Epilepsy (ILAE). Zung Self‐Reporting Depression Scale (ZSRDS) was used to assess the mood of participants. The Community Screening Interview for Dementia (CSID) was used to assess various cognition domains. The National Hospital Seizure Severity Scale (NHS‐3) was used to assess disease severity. Results There were statistical differences between the CZP and LTC groups in all domains of cognition assessed except for orientation. The total CSID scores of the LTC group were 59.2 (4.9) as opposed to CZP group, 57.2 (5.0); p: .005. Those with focal onset seizures had lower median total CSID score (58; IQR: 54–62) when compared to those with generalized onset seizures (62; IQR: 58–62), p: .012. There was a significant correlation between ZSRD score and NHS‐3 score; rho: 0.30, p: .007. Bivariate analysis shows statistically significant correlation between total CSID score and ZSRDS (rho: −0.65), BMI (rho: 0.22), and NHSS‐3 score (rho: −0.36), respectively. However, the effect of AED on CSID scores was lost after multivariate quantile regression with only ZSRDS retaining significance. Conclusion Depression, seizure severity, type and structural etiology were associated with cognitive impairment among WWE. However, on regression model, only depression was statistically significant. The presence of more risks for cognitive impairment in the CZP group limits possible conclusion of LTC superiority.

【 授权许可】

Unknown