Fecal microbiota transplantation in recurrent Clostridium difficile infection in a patient with concomitant inflammatory bowel disease

Revista Espanola de Enfermedades Digestivas

Marta Gravito-Soares¹  Francisco Portela¹  Carlos Sofia¹  Elisa Gravito-Soares¹  Manuela Ferreira¹ 

[1] Coimbra University Hospital;

关键词: Recurrent Clostridium difficile infection;    Ulcerative pancolitis;    Fecal microbiota transplantation;    Inflammatory bowel disease;    Infectious colitis;   

DOI  :  10.17235/reed.2017.4819/2016

来源: DOAJ

【 摘 要 】

The use of fecal microbiota transplantation in recurrent Clostridium difficile infection and coexistent inflammatory bowel disease remains unclear. A 61-year-old man with ulcerative pancolitis was diagnosed with a third recurrence of Clostridium difficile infection, previously treated with metronidazole, vancomycin and fidaxomicin. Fecal microbiota transplantation of an unrelated healthy donor was performed by the lower route. After a twelve month follow-up, the patient remains asymptomatic without Clostridium difficile infection relapses or inflammatory bowel disease flare-ups. Fecal microbiota transplantation is relatively simple to perform, well-tolerated, safe and effective in recurrent Clostridium difficile infection with ulcerative pancolitis, as an alternative in case of antibiotic therapy failure.

【 授权许可】

Unknown