Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Sensors

Giorgio Rispoli¹  Gabriele Anania²  Cesare Malagù³  Vincenzo Guidi³  Matteo Valt³  Nicolò Landini³  Barbara Fabbri³  Giulia Zonta³  Michele Astolfi³ 

[1] Department of Life Sciences and Biotechnology, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy;Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy;Department of Physics and Earth Sciences, University of Ferrara, Via Saragat 1/C, 44122 Ferrara, Italy;

关键词: chemoresistive sensors;    blood;    cells;    tumor;    screening;    metabolites;    oncology;   

DOI  :  10.3390/s20051411

来源: DOAJ

【 摘 要 】

Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research.

【 授权许可】

Unknown