Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Cancers

Rosanna Villani¹  Gaetano Serviddio¹  Moris Sangineto¹  Francesco Cavallone¹  Antonino Romano²  Domenico Loizzi³ 

[1]Centro Universitario per la Ricerca e la Cura delle Epatopatie (C.U.R.E.), Liver Unit, Università di Foggia, 71100 Foggia, Italy

[2]Institute of Internal Medicine, Università di Foggia, 71100 Foggia, Italy

[3]Institute of Thoracic Surgery, Università di Foggia, 71100 Foggia, Italy

关键词: hepatocellular carcinoma;    lipid metabolism;    fatty acid β-oxidation;    lipidomics;    tumour progression;    non-alcoholic fatty liver disease;   

DOI  :  10.3390/cancers12061419

来源: DOAJ

【 摘 要 】

: Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progression of HCC. The aim of this review is to elucidate the mechanisms by which lipid metabolism is involved in hepatocarcinogenesis and tumour adaptation to different conditions, focusing on the transcriptional aberrations with new insights in lipidomics and lipid zonation. This will help detect new putative therapeutic approaches in the second most frequent cause of cancer-related death.

【 授权许可】

Unknown