The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota

Microorganisms

Vanessa Bray¹  Thao Ho¹  SamiaV. O. Dutra²  MaureenW. Groer²  ShenJean Lim²  Miriam Aguilar-Lopez³  SharonM. Donovan³  Christine Wetzel⁴ 

[1] College of Medicine, University of South Florida, Tampa, FL 33612, USA;College of Nursing, University of South Florida, Tampa, FL 33612, USA;Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA;Neonatology Division, Carle Hospital, Urbana, IL 61801, USA;

关键词: preterm infant;    gut microbiota;    human milk;    twins;    triplets;   

DOI  :  10.3390/microorganisms9020278

来源: DOAJ

【 摘 要 】

The preterm infant gut microbiota is influenced by environmental, endogenous, maternal, and genetic factors. Although siblings share similar gut microbial composition, it is not known how genetic relatedness affects alpha diversity and specific taxa abundances in preterm infants. We analyzed the 16S rRNA gene content of stool samples, ≤ and >3 weeks postnatal age, and clinical data from preterm multiplets and singletons at two Neonatal Intensive Care Units (NICUs), Tampa General Hospital (TGH; FL, USA) and Carle Hospital (IL, USA). Weeks on bovine milk-based fortifier (BMF) and weight gain velocity were significant predictors of alpha diversity. Alpha diversity between siblings were significantly correlated, particularly at ≤3 weeks postnatal age and in the TGH NICU, after controlling for clinical factors. Siblings shared higher gut microbial composition similarity compared to unrelated individuals. After residualizing against clinical covariates, 30 common operational taxonomic units were correlated between siblings across time points. These belonged to the bacterial classes Actinobacteria, Bacilli, Bacteroidia, Clostridia, Erysipelotrichia, and Negativicutes. Besides the influence of BMF and weight variables on the gut microbial diversity, our study identified gut microbial similarities between siblings that suggest genetic or shared maternal and environmental effects on the preterm infant gut microbiota.

【 授权许可】

Unknown