Thermosensitive hydrogel for in situ-controlled methotrexate delivery

e-Polymers

Carrillo-Castillo Teresa Darlen¹  Zaragoza-Contreras Erasto Armando¹  Luna-Velasco Antonia²  Castro-Carmona Javier Servando³ 

[1] Department of Engineering and Materials Chemistry, Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, C.P. 31136, Chihuahua, Chih, Mexico;Department of Environment and Energy, Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, C.P. 31136, Chihuahua, Chih, Mexico;Engineering in Design and Agricultural/Food Automation, Universidad Autónoma de Ciudad Juárez, Manuel Díaz H. No. 518-B Zona Pronaf Condominio, C.P. 32315, Ciudad Juárez, Chih, Mexico;

关键词: copolymer;    cytotoxicity;    drug delivery;    hydrogel;    methotrexate;   

DOI  :  10.1515/epoly-2021-0085

来源: DOAJ

【 摘 要 】

MTX is loaded and released in a controlled manner over 14 h, under physiological conditions, from an amphiphilic triblock copolymer with a sol–gel phase change at 36.5°C.

【 授权许可】

Unknown