Advances in the study of RNA-binding proteins in diabetic complications

Molecular Metabolism

Peng Yu¹  Xiao Liu²  Panpan Xia³  Yunfeng Shen³  Jianyong Ma⁴  Jiashu Han⁵  Jiaqiang Wu⁶  Zhangwang Li⁶  Xinyue Chen⁶  Jing Zhang⁶ 

[1] Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Jiangxi, Nanchang 330006, China;Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;Department of Metabolism and Endocrinology, the Second Affiliated Hospital of Nanchang University, Nanchang, China;Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, USA;Department of Thoracic Surgery, Peking Union Medical College Hospital, Beijing 100730, China;The Second Clinical Medical College of Nanchang University, the Second Affiliated Hospital of Nanchang University, Nanchang, China;

关键词: Diabetes;    Diabetic complications;    RNA binding proteins;    Therapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: It has been reported that diabetes mellitus affects 435 million people globally as a primary health care problem. Despite many therapies available, many diabetes remains uncontrolled, giving rise to irreversible diabetic complications that pose significant risks to patients’ wellbeing and survival. Scope of Review: In recent years, as much effort is put into elucidating the posttranscriptional gene regulation network of diabetes and diabetic complications; RNA binding proteins (RBPs) are found to be vital. RBPs regulate gene expression through various post-transcriptional mechanisms, including alternative splicing, RNA export, messenger RNA translation, RNA degradation, and RNA stabilization. Major Conclusions: Here, we summarized recent studies on the roles and mechanisms of RBPs in mediating abnormal gene expression in diabetes and its complications. Moreover, we discussed the potential and theoretical basis of RBPs to treat diabetes and its complications.

【 授权许可】

Unknown