Hair EDX Analysis—A Promising Tool for Micronutrient Status Evaluation of Patients with IBD?

Nutrients

Gabriela Ștefănescu¹  Anca Trifan¹  Manuela Ciocoiu¹  Smaranda Diaconescu¹  Vlad-Adrian Afrăsânie¹  Gheorghe G. Balan¹  Georgiana-Emmanuela Gîlcă-Blanariu¹  Gabriel Dimofte¹  Adina Coroabă²  Tudor Pinteală³ 

[1] Faculty of Medicine, Grigore T Popa University of Medicine and Pharmacy, 700115 Iași, Romania;Petru Poni Institute of Macromolecular Chemistry, 700487 Iași, Romania;Sf Spiridon County Clinical Emergency Hospital, 700111 Iași, Romania;

关键词: inflammatory bowel disease;    micronutrients;    EDX;    trace element;    iron;    zinc;   

DOI  :  10.3390/nu13082572

来源: DOAJ

【 摘 要 】

Micronutrient deficiencies can arise in various conditions, including inflammatory bowel diseases (IBD), and diagnosing these deficiencies can be challenging in the absence of specific clinical signs. The aim of this study was to evaluate the status of various trace elements hair concentration in IBD patients compared to a healthy control group and to identify potential correlations between the micronutrient status and relevant parameters related to disease activity. The concentrations of iron, magnesium, calcium, zinc, copper, manganese, selenium and sulfur in the hair of 37 IBD patients with prior diagnosed IBD (12 Crohn’s disease and 25 ulcerative colitis) and 31 healthy controls were evaluated by Energy Dispersive X-Ray spectroscopy (EDX). Significant differences in hair concentration profile of studied trace elements were identified for IBD patients compared to healthy controls. A significantly decreased hair concentration of iron, magnesium, calcium and selenium and a significantly increased sulfur hair concentration were observed in IBD patients at the time of evaluation. A decreased hair calcium concentration (r = −0.772, p = 0.003) and an increased sulfur concentration (r = 0.585, p = 0.046) were significantly correlated with disease activity. Conclusion: Hair mineral and trace elements evaluation may contribute to a proper evaluation of their status in IBD patients and improving the management of nutritional status of IBD patients.

【 授权许可】

Unknown