Perimortem changes in clinical parameters in patients undergoing maintenance hemodialysis

Renal Replacement Therapy

Nobuko Yamaguchi¹  Kohkichi Morimoto¹  Mototsugu Oya¹  Tadashi Yoshida¹  Takuma Oshida²  Takashin Nakayama²  Shotaro Kosugi²  Takuto Torimitsu² 

[1] Apheresis and Dialysis Center, Keio University School of Medicine;Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine;

关键词: Hemodialysis;    Forgoing;    Withdrawal;    Blood pressure;   

DOI  :  10.1186/s41100-021-00388-y

来源: DOAJ

【 摘 要 】

Abstract Background End-of-life medical care for patients receiving maintenance hemodialysis (HD) therapy has become an increasingly important issue worldwide. Thus far, no clear indicators and/or biomarkers exist regarding the timing of HD therapy withdrawal. Methods To clarify the perimortem circumstances, we examined temporal changes in multiple clinical parameters during the last 10 serial HD sessions of 65 terminal patients with end-stage renal disease who had undergone maintenance HD and died in our hospital. Results The results showed that, while most of the laboratory data were unaltered, the physical parameters, such as systolic blood pressure and consciousness levels, gradually and significantly deteriorated toward the last HD session prior to death. The frequency of the use of vasopressors and O2 inhalation tended to increase. The accumulation of such severe conditions was observed at the last HD session. Of interest, the accumulation of severe conditions at the last HD session in patients with malignancies was significantly less than those with cardiovascular diseases or infectious diseases. The accumulation of severe conditions at the last HD session did not differ between patients who withdrew HD versus those who continued HD. Conclusion The results of the present study suggest that predicting the timing of maintenance HD therapy withdrawal is likely to be difficult and that the timing of maintenance HD therapy termination may differ among patient groups with distinct comorbid conditions.

【 授权许可】

Unknown