期刊论文详细信息
Frontiers in Pharmacology
The Potential of Traditional Knowledge to Develop Effective Medicines for the Treatment of Leishmaniasis
Thamara Sauini1  Eliana Rodrigues1  Erika dos Santos Brunelli1  Thais Fernanda Amorim Pavani2  Luiz Felipe D. Passero3  Jéssica Adriana Jesus5 
[1] Center for Ethnobotanical and Ethnopharmacological Studies (CEE), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;Chemical and Pharmaceutical Research Group (GPQFfesp), Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;Institute for Advanced Studies of Ocean, São Paulo State University (UNESP), São Paulo, Brazil;Institute of Biosciences, São Paulo State University (UNESP), São Paulo, Brazil;Laboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;
关键词: ethnopharmacology;    traditional knowledge;    natural drugs;    leishmaniasis;    medicinal plants;    neglected disease;   
DOI  :  10.3389/fphar.2021.690432
来源: DOAJ
【 摘 要 】

Leishmaniasis is a neglected tropical disease that affects people living in tropical and subtropical areas of the world. There are few therapeutic options for treating this infectious disease, and available drugs induce severe side effects in patients. Different communities have limited access to hospital facilities, as well as classical treatment of leishmaniasis; therefore, they use local natural products as alternative medicines to treat this infectious disease. The present work performed a bibliographic survey worldwide to record plants used by traditional communities to treat leishmaniasis, as well as the uses and peculiarities associated with each plant, which can guide future studies regarding the characterization of new drugs to treat leishmaniasis. A bibliographic survey performed in the PubMed and Scopus databases retrieved 294 articles related to traditional knowledge, medicinal plants and leishmaniasis; however, only 20 were selected based on the traditional use of plants to treat leishmaniasis. Considering such studies, 378 quotes referring to 292 plants (216 species and 76 genera) that have been used to treat leishmaniasis were recorded, which could be grouped into 89 different families. A broad discussion has been presented regarding the most frequent families, including Fabaceae (27 quotes), Araceae (23), Solanaceae and Asteraceae (22 each). Among the available data in the 378 quotes, it was observed that the parts of the plants most frequently used in local medicine were leaves (42.3% of recipes), applied topically (74.6%) and fresh poultices (17.2%). The contribution of Latin America to studies enrolling ethnopharmacological indications to treat leishmaniasis was evident. Of the 292 plants registered, 79 were tested against Leishmania sp. Future studies on leishmanicidal activity could be guided by the 292 plants presented in this study, mainly the five species Carica papaya L. (Caricaceae), Cedrela odorata L. (Meliaceae), Copaifera paupera (Herzog) Dwyer (Fabaceae), Musa × paradisiaca L. (Musaceae), and Nicotiana tabacum L. (Solanaceae), since they are the most frequently cited in articles and by traditional communities.

【 授权许可】

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