New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities

Molecules

Chun-Yu He¹  Duo-Bin Mao¹  Peng-Fei Yang¹  Pei-Cheng Zhang²  Ya-Nan Yang²  Sheng-Chen Zhao³  Qi-Shan Yuan³  Yu-Feng Fu³  Zhi-Fei Chen³ 

[1] College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Technology Center, China Tobacco Henan Industrial Co. Ltd., Zhengzhou 450000, China;

关键词: Chrysanthemum morifolium;    caffeoylquinic acid;    flavanone glycoside;    neuroprotective activity;   

DOI  :  10.3390/molecules24050850

来源: DOAJ

【 摘 要 】

The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4⁻9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1⁻8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

【 授权许可】

Unknown