Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels

Schizophrenia Research: Cognition

Manabu Takaki¹  Taku Sato²  Yuko Okahisa²  Philip D. Harvey³  Tomiki Sumiyoshi⁴  Kenneth L. Subotnik⁴  Ichiro Sora⁵  Chika Sumiyoshi⁶  Keith H. Nuechterlein⁷ 

[1] Research Service, Bruce W. Carter VA Medical Center, Miami, FL, USA;Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Department of Psychiatry School of Medicine, University of Miami Miller School of Medicine;Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA;Department of Regional Liberal Arts, Faculty of Liberal Arts, Iwaki Meisei University, Iwaki, Japan;Faculty of Human Development and Culture, Fukushima University, Fukushima, Japan;Graduate School of Medicine, Department of Psychiatry, Kobe University, Hyōgo, Japan;

关键词: Functional outcomes;    Cognition;    Everyday-living skills;    Social functioning;    Work outcome;   

DOI  :  10.1016/j.scog.2015.07.003

来源: DOAJ

【 摘 要 】

Functional outcomes in individuals with schizophrenia suggest recovery of cognitive, everyday, and social functioning. Specifically improvement of work status is considered to be most important for their independent living and self-efficacy. The main purposes of the present study were 1) to identify which outcome factors predict occupational functioning, quantified as work hours, and 2) to provide cut-offs on the scales for those factors to attain better work status. Forty-five Japanese patients with schizophrenia and 111 healthy controls entered the study. Cognition, capacity for everyday activities, and social functioning were assessed by the Japanese versions of the MATRICS Cognitive Consensus Battery (MCCB), the UCSD Performance-based Skills Assessment-Brief (UPSA-B), and the Social Functioning Scale Individuals’ version modified for the MATRICS-PASS (Modified SFS for PASS), respectively. Potential factors for work outcome were estimated by multiple linear regression analyses (predicting work hours directly) and a multiple logistic regression analyses (predicting dichotomized work status based on work hours). ROC curve analyses were performed to determine cut-off points for differentiating between the better- and poor work status. The results showed that a cognitive component, comprising visual/verbal learning and emotional management, and a social functioning component, comprising independent living and vocational functioning, were potential factors for predicting work hours/status. Cut-off points obtained in ROC analyses indicated that 60–70% achievements on the measures of those factors were expected to maintain the better work status. Our findings suggest that improvement on specific aspects of cognitive and social functioning are important for work outcome in patients with schizophrenia.

【 授权许可】

Unknown