Challenges for the Implantation of Symbiotic Nanostructured Medical Devices

Applied Sciences

Jacques Thélu¹  Géraldine Penven¹  Abdelkader Zebda¹  DonaldK. Martin¹  Philippe Cinquin¹  Gauthier Menassol¹  Jean-Pierre Alcaraz¹  Sarra El Ichi¹ 

[1] Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG/SyNaBi (UMR 5525), 38000 Grenoble, France;

关键词: symbiotic;    biocompatibility;    bioinspiration;    nanobiotechnology;    implanted medical device;   

DOI  :  10.3390/app10082923

来源: DOAJ

【 摘 要 】

We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends the existing concepts of a biomaterial and biocompatibility to include the notion that it is important to consider the intended functional use of the implanted medical device. This demands a biomimetic approach to design functional symbiotic implantable medical devices that can be more efficient in mimicking what is happening at the molecular and cellular levels to create stable interfaces that allow for the unfettered exchanges of molecules between an implanted device and a body. Such a duplex level of communication is considered to be a necessary characteristic of symbiotic implanted medical devices that are designed to function for long periods of time inside the body to restore and assist the function of the body. We illustrate these perspectives with experience gained from implanting functional enzymatic biofuel cells.

【 授权许可】

Unknown