Primary progressive aphasia

Nevrologiâ, Nejropsihiatriâ, Psihosomatika

N. I. Ananieva¹  I. K. Stulov¹  Yu. V. Kotsiubinskaya¹  N. Yu. Safonova¹  V. A. Mikhailov¹ 

[1] Bekhterev National Medical Research Center for Psychiatry and Neurology, Ministry of Health of Russia;

关键词: primary progressive aphasia;    dementia;    tau protein;    beta amyloid;    magnetic resonance imaging with morphometry;   

DOI  :  10.14412/2074-2711-2019-1-4-11

来源: DOAJ

【 摘 要 】

Primary progressive aphasia (PPA) is a heterogeneous group of neurodegenerative diseases related to focal degenerations of the brain and mainly manifested by a gradual loss of speech functions. This symptom is characterized by specific speech disorders. The article presents the etiopathogenic features of PPA, systematizes the clinical criteria for its diagnosis, and describes the modern neuroimaging characteristics of different types of PPA. The proposed PPA severity point scale allows clinicians to record the very early manifestations of aphasia. Modified scales, such as the Frontal Behavioral Inventory (FBI-mod) and the Clinical Dementia Rating (CDR), are also important for specifying the type of PPA.

【 授权许可】

Unknown