Effect of Early Supplemental Formula Intervention on Body Weight and Hyperbilirubinemia in Neonates During 72 h After Birth

Frontiers in Pediatrics

Han-Ping Wu²  En-Pei Lee³  Lu-Lu Zhao⁴  Su-Cheng Huang⁷  Stephen Shei-Dei Yang⁹  Raymond Nein-Chen Kuo^1,10 

[1] 0Department of Medicine, School of Medicine, China Medical University, Taichung, Taiwan;1Department of Medical Research, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan;College of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan;Department of Pediatric Emergency Medicine, China Medical University Children's Hospital, Taichung, Taiwan;Department of Pediatrics, Taipei Tzu Chi Hospital, New Taipei, Taiwan;Division of Obstetrics and Gynecology, Taipei Tzu Chi Hospital, New Taipei, Taiwan;Division of Pediatric Critical Care Medicine, and Pediatric Sepsis Study Group, Department of Pediatrics, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan;Division of Urology, Taipei Tzu Chi Hospital, New Taipei, Taiwan;Innovation and Policy Center for Population Health and Sustainable Environment, College of Public Health, National Taiwan University, Taipei, Taiwan;Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan;

关键词: dehydration;    jaundice;    breastfeeding;    body weight loss;    neonate;   

DOI  :  10.3389/fped.2021.625536

来源: DOAJ

【 摘 要 】

Background: The full breastfeeding may lead to insufficient milk intake of newborns and increase the rate of body weight loss (BWL). Severe BWL was generally believed as a cause of significant hyperbilirubinemia in newborn babies. The study aimed to investigate the effect if early supplemental feeding in newborns with birth weight loss at the first 3 days after birth could decrease the rate of hyperbilirubinemia 72 h of birth.Methods: A total of 395 neonates with gestational age >37 weeks and birth body weight >2500g were prospectively collected between 2016 and 2018. We analyzed 280 neonates with BWL rate reaching the predictive value (4.5%, 7.5%, and 8% on the first, second, third day after birth, respectively) for subsequent hyperbilirubinemia after 72 hours after birth. The enrolled cases were divided into four subgroups as interventional consecutive milk supplement for 0, 1, 2, and 3 days after birth for further analysisResults: For newborns with BWL reaching the predictive value on the first day after birth, the serum bilirubin levels were lower in the experimental group than those in the non-involved control group (p < 0.05). For newborns with three consecutive days of interventional milk supplementation, the serum bilirubin levels at the 72 h after birth showed the lowest levels compared with the other sub-groups with two consecutive days and one consecutive day of interventional milk supplementation (p < 0.05). Moreover, there was a significantly decreasing trend in the consecutive days of interventional milk supplementation (p < 0.05).Conclusion: Newborns with BWL over 4.5% on the first day after birth receiving early intervention milk supplementation could significantly reduce serum bilirubin levels at the72 h after birth. The more days of consecutive milk supplementation after birth may lead to the lower the 72 h serum bilirubin levels. It is recommended to early and consecutive milk supplementation after birth to be an effective way in reducing serum bilirubin levels.

【 授权许可】

Unknown