Micromotor Manipulation Using Ultrasonic Active Traveling Waves

Micromachines

Han-Sol Lee¹  Minghui Nan¹  Chang-Sei Kim¹  Byungjeon Kang¹  HiepXuan Cao¹  Eunpyo Choi¹  Daewon Jung¹  Gwangjoon Go¹  Jong-Oh Park¹ 

[1] Korea Institute of Medical Microrobotics, Gwangju 506813, Korea;

关键词: acoustic manipulation;    active traveling wave;    ultrasonic actuation;    non-contact manipulation;    particle manipulation;    targeted drug delivery;   

DOI  :  10.3390/mi12020192

来源: DOAJ

【 摘 要 】

The ability to manipulate therapeutic agents in fluids is of interest to improve the efficiency of targeted drug delivery. Ultrasonic manipulation has great potential in the field of therapeutic applications as it can trap and manipulate micro-scale objects. Recently, several methods of ultrasonic manipulation have been studied through standing wave, traveling wave, and acoustic streaming. Among them, the traveling wave based ultrasonic manipulation is showing more advantage for in vivo environments. In this paper, we present a novel ultrasonic transducer (UT) array with a hemispherical arrangement that generates active traveling waves with phase modulation to manipulate a micromotor in water. The feasibility of the method could be demonstrated by in vitro and ex vivo experiments conducted using a UT array with 16 transducers operating at 1 MHz. The phase of each transducer was controlled independently for generating a twin trap and manipulation of a micromotor in 3D space. This study shows that the ultrasonic manipulation device using active traveling waves is a versatile tool that can be used for precise manipulation of a micromotor inserted in a human body and targeted for drug delivery.

【 授权许可】

Unknown