MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population

AIMS Genetics

Gholamreza Bahari¹  Mohammad Hadi Radfar¹  Saeid Ghavami¹  Behzad Narouie²  Fatemeh Bizhani³  Hiva Danesh³  Mohsen Taheri⁴  Mehdi Sotoudeh⁴  Mehdi Honarkar Ramezani⁴ 

[1] Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;;Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;Urology and Nephrology Research Center;

关键词: miR-608;    bladder cancer;    polymorphism;   

DOI  :  10.3934/genet.2016.4.212

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) participate in diverse biological pathways and mayact as oncogenes or tumor suppressors. The single nucleotide polymorphisms(SNPs) in miRNAs potentially can alter miRNA-binding sites on target genes aswell as affecting miRNAs expression. Thepresent study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on bladder cancer risk. This case-control study conducted on 233 bladder cancer patients and 252healthy subjects. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment lengthpolymorphism (PCR-RFLP) method.Our findings showed that CG as well as CG+GG genotypes significantlyincreased the risk of bladder cancer (OR = 1.94, 95% CI = 1.28–2.94, p = 0.002, and OR = 1.90,95% CI = 1.26–2.86, p = 0.002, respectively) compared to CC genotype. The G allele significantly increased the risk of bladdercancer compared to C allele (OR = 1.69, 95% CI = 1.17–2.45, p = 0.005). Our findings proposed that miR-608 polymorphism might beassociated with increased risk of bladder cancer in a sample of Iranianpopulation. Further large-scale studies with different ethnicities are neededto verify our findings

【 授权许可】

Unknown