Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

International Journal of Behavioral Nutrition and Physical Activity

On behalf of the PREDIMED-Plus investigators¹  Vicente Martín²  José Juan Gaforio²  Laura Torres-Collado²  Jesús Vioque²  Antonio Garcia-Rios³  Emilio Ros³  Dora Romaguera³  Fernando Arós³  Josep Basora³  J. Alfredo Martínez³  Ascensión Marcos³  Itziar Abete³  Clotilde Vázquez³  Jordi Salas-Salvadó³  Ramon Estruch³  Julia Warnberg³  Dolores Corella³  Aurora Bueno-Cavanillas³  Lluis Serra-Majem³  Xavier Pintó³  Josep A. Tur³  José López Miranda³  Francisco J. Tinahones³  José Lapetra³  Mònica Bullo³  Eva M. Asensio³  Helmut Schröder⁴  Olga Castañer⁴  Montserrat Fitó⁴  Gabriela Cárdenas-Fuentes⁴  Albert Goday⁴  Josep Vidal⁵  Pilar Matía-Martín⁶  Miguel Ruiz-Canela⁷  Pilar Buil-Cosiales⁷  Miguel Angel Martínez-González⁷  Estefania Toledo⁷  Lidia Daimiel⁸  Camille Lassale⁹ 

[1] ;CIBER Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III;CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III;Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar, Medical Research Institute (IMIM);Department of Endocrinology and Nutrition, Hospital Clínic;Department of Endocrinology and Nutrition, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IDISSC);Department of Preventive Medicine and Public Health, University of Navarra-Navarra Institute for Health Research;Nutritional Genomics and Epigenomics group, Madrid Institute for Advanced Studies (IMDEA) Food Institute, CEI UAM + CSIC;Research Department of Epidemiology & Public Health, University College London;

关键词: Randomized control trial;    Physical activity;    Older adults;    Intervention program;    Body mass index;    Waist circumference;   

DOI  :  10.1186/s12966-018-0741-x

来源: DOAJ

【 摘 要 】

Abstract Background The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component. Methods PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups. Results After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7–136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p < 0.01) in both groups. A significant (p < 0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA. Conclusion After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults. Trial registration Retrospectively registered at the International Standard Randomized Controlled Trial (http://www.isrctn.com/ISRCTN89898870), registration date: 24 July 2014.

【 授权许可】

Unknown