Theanine supplementation prevents liver injury and heat shock response by normalizing hypothalamic-pituitaryadrenal axis hyperactivity in mice subjected to whole body heat stress

Journal of Functional Foods

Taotao Wang¹  Chi-Tang Ho²  Min Cai²  Jinbao Huang²  Haisong Wang³  Guangshan Zhao⁴  Dongxu Wang⁴  Frank Qian⁴  Yijun Wang⁴ 

[1] International Joint Laboratory on Tea Chemistry and Health Effects, Anhui Agricultural University, Hefei, Anhui 230036, PR China;Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China;Department of Clinical Nutrition, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, PR China;;State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science &

关键词: Theanine;    Heat stress;    Liver injury;    Heat shock response;    HPA axis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Thermal stress evokes heat shock response and activates hypothalamic-pituitaryadrenal (HPA) axis. Additionally, liver injury is an important adverse effect of thermal stress. Considering the anti-stress effects of theanine, an amino acid found in tea plants, we hypothesized that theanine may protect against heat stress. Mice were administered intragastrically with theanine prior to whole body thermal exposure. Theanine prevented the heat-induced upregulation of heat shock proteins and reduced the heat-induced liver damage and oxidative stress. Theanine significantly prevented the heat-induced effects on inflammatory and acute phase responses as measured by plasma inflammatory cytokine concentrations, hepatic inflammatory cytokine mRNA levels, plasma nitric oxide and C-reactive protein levels. Additionally, theanine supplementation suppressed heat stress-related disorders associated with normalizing HPA axis hyperactivity. These findings suggest that theanine can have beneficial effects against heat stress and may be an attractive dietary application for people who are at high risk of developing heat stress.

【 授权许可】

Unknown