The clinical and microbiological efficacy of vancomycin in the combination treatment of newborns with ventilator-associated pneumonia caused by gram-positive cocci

Rossijskij Vestnik Perinatologii i Pediatrii

G. M. Dementyeva¹  A. Yu. Gerasimov²  M. V. Kushnareva² 

[1] Maternity Hospital Fifteen, Moscow;Research Clinical Institute of Pediatrics;

关键词: infants;    neonates;    pneumonia;    vancomycin;   

DOI  :  

来源: DOAJ

【 摘 要 】

The paper deals with nosocomlal ventilator-associated pneumonia caused by gram-positive cocci in full-term and preterm newborns and with a trial of the clinical and microbiological efficacy of the antibiotic vancomycin. Thirteen full-term neonates and 46 preterm ones were examined. Most newborn infants (78—93%) were found to have monoinfection caused by gram-positive cocci, mainly Staphylococcus spp. and Enterococcus faecalis. Vancomycin was highly effective against the coccal microflora with the minimum inhibitory concentration (MIC) of <2 ug/ml against Staphylococcus spp. and Group В Streptococcus in 46 newborns, moderately effective with the MIC of 24 ug/ml, but s8 ug/ml against Enterococcus faecalis m9 infants and ineffective or lowly effective with the MIC of 216 ug/ml against Enterococcus faecium in 4 infants. However, secondary infection caused by the hospital strains of gram-negative microorganisms (predominantly Enterobacteriaceae and Pseudomonasaeruginosae) generally inducing mixed infection occurred in 41% of the infants on 5—7 day of the disease. In this connection, most children were given vancomycin in combination with beta-lactam antibiotics or amikacin.

【 授权许可】

Unknown