Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

Frontiers in Pediatrics

Susan J. Pizzutto¹  Kim M. Hare¹  John W. Upham³ 

[1] Child Health Division, Menzies School of Health Research, Darwin, NT, Australia;Department of Respiratory Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia;School of Medicine, The University of Queensland, Brisbane, QLD, Australia;

关键词: bronchiectasis;    children;    immunology;    microbiology;    chronic suppurative lung disease;   

DOI  :  10.3389/fped.2017.00123

来源: DOAJ

【 摘 要 】

Bronchiectasis is a complex chronic respiratory condition traditionally characterized by chronic infection, airway inflammation, and progressive decline in lung function. Early diagnosis and intensive treatment protocols can stabilize or even improve the clinical prognosis of children with bronchiectasis. However, understanding the host immunologic mechanisms that contribute to recurrent infection and prolonged inflammation has been identified as an important area of research that would contribute substantially to effective prevention strategies for children at risk of bronchiectasis. This review will focus on the current understanding of the role of the host immune response and important pathogens in the pathogenesis of bronchiectasis (not associated with cystic fibrosis) in children.

【 授权许可】

Unknown