The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients

BMC Infectious Diseases

Yeming Wang¹  Rui Qin²  Qi Long²  Liulin Wang²  Jing Li²  Gang Li²  Qiufen Dong²  Min Wang²  Dan Li²  Juan Liu²  Xiaobin Cheng²  Bin Song³  Chenliang Zhou⁴  Yuanming Ba⁵  Weinan Li⁵ 

[1] Department of Critical Care Medicine, Hubei Provincial Hospital of Integrated Chinese & Western Medicine;Department of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese Medicine;Department of Critical Care Medicine, Jin Yin-tan Hospital;Department of Critical Care Medicine, Renmin Hospital of Wuhan University;Hubei Provincial Academy of Tranditional Chinese Medicine;

关键词: COVID-19;    Laboratory tests;    Cox proportional hazards model;    Risk factors;   

DOI  :  10.1186/s12879-021-06057-z

来源: DOAJ

【 摘 要 】

Abstract Background The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Methods We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. Results In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. Conclusions COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.

【 授权许可】

Unknown