期刊论文详细信息
Frontiers in Chemistry | |
Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds | |
Christian Mang1  Jörn Saupe1  Andrea Basso2  Fabio De Moliner2  Lisa Moni2  Silvia Garbarino2  | |
[1] AnalytiCon Discovery GmbH, Potsdam, Germany;Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Genova, Italy; | |
关键词: multicomponent reactions; diversity oriented synthesis; scaffold diversity; combinatorial libraries; isocyanides; | |
DOI : 10.3389/fchem.2018.00369 | |
来源: DOAJ |
【 摘 要 】
An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.
【 授权许可】
Unknown