Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

Frontiers in Chemistry

Christian Mang¹  Jörn Saupe¹  Andrea Basso²  Fabio De Moliner²  Lisa Moni²  Silvia Garbarino² 

[1] AnalytiCon Discovery GmbH, Potsdam, Germany;Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Genova, Italy;

关键词: multicomponent reactions;    diversity oriented synthesis;    scaffold diversity;    combinatorial libraries;    isocyanides;   

DOI  :  10.3389/fchem.2018.00369

来源: DOAJ

【 摘 要 】

An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.

【 授权许可】

Unknown