A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling

Frontiers in Cell and Developmental Biology

Hajir eAl Saihati¹  John ePrimrose¹  Rahul eBhome¹  Marc eBullock¹  Rebecca eGoh¹  Alexander eMirnezami¹  A. Emre eSayan¹ 

[1] University of Southampton;University of Texas;

关键词: Extracellular Matrix;    MicroRNAs;    Tumor Microenvironment;    Cancer-associated fibroblast;    Cancer stroma;   

DOI  :  10.3389/fcell.2015.00033

来源: DOAJ

【 摘 要 】

It is well established that the tumour microenvironment contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular and immune. Signalling molecules secreted by the tumour corrupts these cells to create ‘activated’ stroma. Equally, the extracellular matrix contributes to tumour development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signalling components of the tumour microenvironment with a perspective on stromal soluble factors and microRNAs.

【 授权许可】

Unknown