Tolerogenic Role of Myeloid Suppressor Cells in Organ Transplantation

Frontiers in Immunology

Alberto Utrero-Rico²  Jordi Ochando³  Patricia Conde³  Estela Paz-Artal⁴ 

[1] Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Grupo de Inmunodeficiencias e Inmunología del Trasplante, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain;Immunología de Trasplantes, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain;School of Medicine, Complutense University, Madrid, Spain;

关键词: MDSC;    immune tolerance;    transplantation;    immunophenotyping;    myeloid cells;   

DOI  :  10.3389/fimmu.2019.00374

来源: DOAJ

【 摘 要 】

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strategies that regulate the induction and development of MDSC have been the center of scientist attention. Here we review literature regarding induction of MDSC with demonstrated suppressive function among different types of allografts and their mechanism of action. While manipulation of MDSC represents a potential therapeutic approach for the promotion of donor specific tolerance in solid organ transplantation, further characterization of their specific phenotype, which distinguishes MDSC from non-suppressive myeloid cells, and detailed evaluation of the inhibitory mechanism that determines their suppressive function, is necessary for the realistic application of MDSC as biomarkers in health and disease and their potential use as immune cell therapy in organ transplantation.

【 授权许可】

Unknown