Transcranial stimulation in frontotemporal dementia: A randomized, double‐blind, sham‐controlled trial

Alzheimer’s & Dementia: Translational Research & Clinical Interventions

Luisa Benussi¹  Valentina Dell'Era²  Chiara Brattini²  Barbara Borroni²  Valentina Cantoni²  Alberto Benussi²  Maura Cosseddu³  Antonella Alberici³  Maria Sofia Cotelli⁴  Maria Cotelli⁵  Rosa Manenti⁵ 

[1] Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy;Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy;Neurology Unit Spedali Civili Hospital Brescia Italy;Neurology Unit Valle Camonica Hospital Esine Brescia Italy;Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy;

关键词: clinical trial;    frontotemporal dementia;    granulin;    presymptomatic;    short interval intracortical inhibition;    transcranial direct current stimulation;   

DOI  :  10.1002/trc2.12033

来源: DOAJ

【 摘 要 】

Abstract Introduction Frontotemporal dementia (FTD) is a progressive disease for which no curative treatment is currently available. We aimed to determine whether transcranial direct current stimulation (tDCS) can modulate intracortical connectivity and improve cognition in symptomatic FTD patients and presymptomatic FTD subjects. Methods We performed a double‐blind, randomized, sham‐controlled trial with anodal tDCS or sham stimulation over the left prefrontal cortex in 70 participants (15 presymptomatic and 55 symptomatic FTD). Results We observed a significant increase of intracortical connectivity (short interval intracortical inhibition and facilitation) and improvement in clinical scores and behavioral disturbances in both symptomatic FTD patients and presymptomatic carriers after real tDCS but not after sham stimulation. Discussion A 2‐weeks’ treatment with anodal left prefrontal tDCS improves symptoms and restores intracortical inhibitory and excitatory circuits in both symptomatic FTD patients and presymptomatic carriers. tDCS might represent a promising future therapeutic and rehabilitative approach in patients with FTD.

【 授权许可】

Unknown