Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics

Frontiers in Nutrition

Konstantinos P. Letsas¹  Christos A. Goudis²  Gregory Y. H. Lip³  Gary Tse⁴  Panagiotis Korantzopoulos⁵  Yueying Wang⁸  Daiqi Liu⁸  Ziliang Chen⁸  Zhiwei Zhang⁸  Guangping Li⁸  Tong Liu⁸  Nan Zhang⁸ 

[1] Arrhythmia Unit, Laboratory of Cardiac Pacing and Electrophysiology, Onassis Cardiac Surgery Center, Athens, Greece;Department of Cardiology, Serres General Hospital, Serres, Greece;Department of Clinical Medicine, Aalborg University, Aalborg, Denmark;Epidemiology Research Unit, Cardiovascular Analytics Group, Hong Kong, China;First Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece;Kent and Medway Medical School, Canterbury, United Kingdom;Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom;Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China;

关键词: vitamin D;    Mendelian randomization;    single-nucleotide polymorphisms;    causal association;    atrial fibrillation;   

DOI  :  10.3389/fnut.2022.842392

来源: DOAJ

【 摘 要 】

Background and AimsVitamin D deficiency is a common disorder and has been linked with atrial fibrillation (AF) in several observational studies, although the causal relationships remain unclear. We conducted a Mendelian randomization (MR) analysis to determine the causal association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and AF.Methods and ResultsThe analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from large genome-wide association meta-analyses conducted on serum 25(OH)D (N = 79,366) and AF (N = 1,030,836). Six SNPs related to serum 25(OH)D were used as instrumental variables. The association between 25(OH)D and AF was estimated using both the fixed-effect and random-effects inverse variance weighted (IVW) method. The MR analyses found no evidence to support a causal association between circulating 25(OH)D level and risk of AF using random-effects IVW (odds ratio per unit increase in log 25(OH)D = 1.003, 95% CI, 0.841–1.196; P = 0.976) or fixed-effect IVW method (OR = 1.003, 95% CI, 0.876–1.148; P = 0.968). Sensitivity analyses yielded similar results. No heterogeneity and directional pleiotropy were detected.ConclusionUsing summary statistics, this MR study suggests that genetically predicted circulating vitamin D concentrations, especially for a non-deficient range, were not causally associated with AF in the general population. Future studies using non-linear design and focusing on the vitamin D deficiency population are needed to further evaluate the causal effect of vitamin D concentrations on AF.

【 授权许可】

Unknown