Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses

Frontiers in Pharmacology

Hong-Ki Lee¹  Sung-Hoon Lee¹  Dooil Jeoung²  Yoojung Kwon²  Youngmi Kim²  Hyun Suk Jung²  Yeongseo Park²  Misun Kim² 

[1] Biotechnology Institute, EHL-BIO Co., Ltd., Uiwang, South Korea;Department of Biochemistry, Kangwon National University, Chunchon, South Korea;

关键词: adipose tissue-derived stem cells;    atopic dermatitis;    targets of stem cells;    cellular interactions;    MIP-2;    miR-122a-5p;   

DOI  :  10.3389/fphar.2018.01175

来源: DOAJ

【 摘 要 】

The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine released, and prostaglandin E2 level. Atopic dermatitis increased the expression levels of cytokines/chemokines, such as interleukin-5 (IL-5), macrophage inflammatory protein-1ß (MIP-1ß), MIP-2, chemokine (C-C motif) ligand 5 (CCL5), and IL-17, in BALB/c mouse. The AdMSCs showed decreased expression levels of these cytokines in the mouse model of AD. In vivo downregulation of MIP-2 attenuated the clinical symptoms associated with AD. Atopic dermatitis increased the expression levels of hallmarks of allergic inflammation, induced interactions of Fc

【 授权许可】

Unknown