Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

Nutrients

Yijing Chen¹  Yu Chen¹  Jinying Xu¹ 

[1] Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen–Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China;

关键词: gut microbiota;    neurotransmitters;    cognition;    neurodegeneration;    Alzheimer’s disease;   

DOI  :  10.3390/nu13062099

来源: DOAJ

【 摘 要 】

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among the metabolic, peripheral immune, and central nervous systems via the microbiota–gut–brain axis. However, it is not well understood how the gut microbiome and neurons in the brain mutually interact or how these interactions affect normal brain functioning and cognition. We summarize the mechanisms whereby the gut microbiota regulate the production, transportation, and functioning of neurotransmitters. We also discuss how microbiome dysbiosis affects cognitive function, especially in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

【 授权许可】

Unknown