Risk factors and distribution of oncogenic strains of human papilloma virus in women presenting for cervical cancer screening in Port Harcourt, Nigeria

The Pan African Medical Journal

Bassey Goddy¹  Durugbo Ikechukwu¹  Nyengidiki Tamunomie Kennedy¹ 

[1] Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria;

关键词: hpv;    prevalence;    risk factors;    port harcourt;    nigeria;   

DOI  :  10.11604/pamj.2016.23.85.8510

来源: DOAJ

【 摘 要 】

INTRODUCTION: human papilloma virus(HPV) accounts for most cases of cervical cancer with high risk HPV(hrHPV) genotypes largely responsible. The objective is to ascertain the distribution of oncogenic strains of human papilloma virus genotypes and predisposing risk factors in women presenting for cervical cancer screening in Nigeria. METHODS: a cross-sectional study of 80 women who presented for cervical cancer screening. The biodata of the participants, the presence of risk factors to HPV were recorded and hrHPV were identified using PCR technique. The information obtained was processed using the SPSS version 20 software. Results were presented in tables, tested for significance and association doneusing student's t-test and Odds ratio with P value = 0.05 as significant. RESULTS: the age range of patients was 19-62 years with prevalence of hrHPV of 10%. HrHPV are more in patients with more than one life time sexual partner (OR 1.26,95%CI 0.13-29.99), multiple sexual partners (OR 1.55, 95% CI 0.28-8.70), early coitarche (OR 1.57, 95% CI 0.14-15.00) and previous STI (OR 150, 95%CI 9.53-1979. 62). Four hrHPV genotypes: 16, 18, 31 and 35 were detected. CONCLUSION: HPV genotype 18 was predominant in Port Harcourt, Nigeria. Highrisk sexual behaviours are associated with acquisition of hrHPV.

【 授权许可】

Unknown