NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction

Cells

Jonggwan Park¹  Moon-Chang Choi²  Jiwon Jo²  HeeKyoung Kang²  Yoonkyung Park² 

[1] Department of Bioinformatics, Kongju National University, Kongju 38065, Korea;Department of Biomedical Science, Chosun University, Gwangju 61452, Korea;

关键词: NF-κB;    osteoarthritis;    cartilage degeneration;    chondrocyte catabolism;    chondrocyte apoptosis;    IκBζ;   

DOI  :  10.3390/cells8070734

来源: DOAJ

【 摘 要 】

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation, and aging. Mechanical stress along with synovial inflammation promotes the degradation of the extracellular matrix in the cartilage, leading to the breakdown of joint cartilage. The nuclear factor-kappaB (NF-κB) transcription factor has long been recognized as a disease-contributing factor and, thus, has become a therapeutic target for OA. Because NF-κB is a versatile and multi-functional transcription factor involved in various biological processes, a comprehensive understanding of the functions or regulation of NF-κB in the OA pathology will aid in the development of targeted therapeutic strategies to protect the cartilage from OA damage and reduce the risk of potential side-effects. In this review, we discuss the roles of NF-κB in OA chondrocytes and related signaling pathways, including recent findings, to better understand pathological cartilage remodeling and provide potential therapeutic targets that can interfere with NF-κB signaling for OA treatment.

【 授权许可】

Unknown