COMBINATION OF A MINIMAL DOSAGE OF DEPOT MEDROXY PROGESTERONE ACETATE AND JAVANESSE LONG PEPPER EXTRACT ON THE BODY WEIGHT, HEMATOLOGY, AND BLOOD BIOCHEMISTRY OF MALE RATS AS A SAFETY CONTRACEPTION MODEL

Makara Seri Sains

关键词: blood biochemistry;    body weight;    DMPA;    hematology;    JLP;   

DOI  :  

来源: DOAJ

【 摘 要 】

The development of male hormonal contraception is based on the decrease in the sperm concentration and it does notaffect libido and sexual potency. The combination of depot medroxy progesterone acetate (DMPA) + extract ofJavanese long pepper (JLP) with dosages of 0.94 mg and 1.88 mg decreases the concentration of spermatozoa.However, it remains unknown whether the combination influences body weight, hematology, and blood biochemistry.Therefore, it is necessary to investigate the effect of DMPA + JLP extracts on the body weight, hematology, and bloodbiochemistry of male rats (Rattus norvegicus L.) strains of Sprague-Dawley. The research uses a completelyrandomized design (CRD); one group control and two treatment groups. In the first group, the castration rats were givenoral administration extracts of JLP (CJ) with doses of 0, 0.94, 1.88, 2.82, and 3.76 mg. In the second group, the ratswere injected with 1.25 mg DMPA and given an oral administration extract of JLP. Injection was given in week-0 and12. Administration was conducted every day from week 7-18. Analysis of the normality and homogeneity of data isdone before the test ANOVA. Data that is abnormal and not homogeneous are tested with non-parametric statisticalKruskal-Wallis. This study shows that the combination of minimal doses of DMPA and administration various doses ofextracts of JLP does not affect body weight and hematology (erythrocyte, hemoglobin, hematocrite), and the bloodbiochemistry of rats, such as the values of SGPT, SGOT, HDL, and triglycerides (p < 0.05), but rather the totalcholesterol and LDL (p < 0.05). Furthermore, it is concluded that the combination of the minimal dosage of DMPA andweaned various dosages of JLP extracts affect the total value and LDL cholesterol but do not influence body weight,nor hematology and blood biochemistry. Such combination can be drawn on for a male contraceptive model that is safeby taking into account the value of the total cholesterol and LDL during its use.

【 授权许可】

Unknown