An Insight into Cotton Leaf Curl Multan Betasatellite, the Most Important Component of Cotton Leaf Curl Disease Complex

Viruses

Muhammad Zubair¹  Shahid Mansoor¹  Imran Amin¹  Sara Shakir¹  Syed Shan-e-Ali Zaidi¹ 

[1] National Institute for Biotechnology and Genetic Engineering, 38000 Faisalabad, Pakistan;

关键词: Cotton leaf curl Multan betasatellite;    βC1;    begomovirus;    leaf curl disease;    Gossypium;   

DOI  :  10.3390/v9100280

来源: DOAJ

【 摘 要 】

Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific satellite, Cotton leaf curl Multan betasatellite (CLCuMuB) belonging to a newly-established family Tolecusatellitidae (genus Betasatellite). CLCuMuB has a small genome (ca. 1350 nt) with a satellite conserved region, an adenine-rich region and a single gene that encodes for a multifunctional βC1 protein. CLCuMuB βC1 protein has a major role in pathogenicity and symptom determination, and alters several host cellular functions like autophagy, ubiquitination, and suppression of gene silencing, to assist CLCuD infectivity. Efficient trans-replication ability of CLCuMuB with several monopartite and bipartite begomoviruses, is also associated with the rapid evolution and spread of CLCuMuB. In this article we comprehensively reviewed the role of CLCuMuB in CLCuD, focusing on the βC1 functions and its interactions with host proteins.

【 授权许可】

Unknown