Perbandingan Osmolaritas Plasma Setelah Pemberian Manitol 20% 3 mL/kgBB dengan Natrium Laktat Hipertonik 3 mL/kgBB pada Pasien Cedera Otak Traumatik Ringan-Sedang

Jurnal Anestesi Perioperatif

Chairul Mursin¹  Budi Harto Batubara¹  Nazaruddin Umar¹ 

[1] Departemen Anestesiologi dan Terapi IntensifFakultas Kedokteran Universitas Sumatera Utara/RSUP H. Adam Malik Medan;

关键词: Hypertonic natrium lactate;    mannitol 20%;    osmolarity;    traumatic brain injury;   

DOI  :  10.15851/jap.v4n3.677

来源: DOAJ

【 摘 要 】

Osmotic therapy is one of many modalities to manage traumatic brain injuries aimed to decrease intracranial pressure by alleviating the brain edema. A study was performed on 30 subjects with mild and moderate brain injuries admitted to the emergency department of Adam Malik General Hospital Medan during October–December 2015 whomeet the inclusion and exclusion criteria. Subjects were divided randomly into 2 treatment groups, i.e. group A that received mannitol 20% 3 mL/kgBW and group B that received hypertonic natrium lactate 3mL/kgBW. The measurement of osmolarity was performed before administration of either of mannitol andhypertonic natrium lactate and at 60 minutes after the administration by drawing the blood for blood check. . Data were statistically analyzed using T- independent test and Mann-Whitney test. Plasma osmolarity changes before and after the treatment were not statistically sifgnificant(p>0.05) for each group treatment even though post-treatment plasma osmolarity was statistically significant. Urin output in the mannitol group was higher than in the hypertonic sodium lactate group and was statistically significant (p>0.05); nevertheless, there was no significant difference in the hemodynamic change. Therefore, manitol is better than hypertonic natrium lactate for osmolarity target therapy in patients mild-moderate head injury.

【 授权许可】

Unknown