Safety and Efficacy of Adjunctive Therapy With Artesunate in the Treatment of Severe Malaria: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology

Hongying Zhang¹  Yexiao Tang¹  Wanting Wu¹  Wenfeng Guo¹  Jianping Song¹  Fei Tuo¹  Ziyi Pan¹  Changqing Li¹  Qin Xu¹  Xinan Huang¹  Qi Wang¹  Yuanyuan Zou¹  Zhiqi Zhang¹  Changsheng Deng¹  Nadia Julie¹  Zhiyong Xu²  Jiawen Guo²  Yueming Yuan² 

[1] Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China;Institute of Science and Technology, Guangzhou University of Chinese Medicine, Guangzhou, China;

关键词: meta-analysis;    severe malaria;    systematic review;    safety;    efficacy;    artesunate;   

DOI  :  10.3389/fphar.2020.596697

来源: DOAJ

【 摘 要 】

Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple databases with the search terms “artesunate” and “adjunctive therapy” and “severe malaria” in July 2020. If the search showed a randomized controlled trial, the study was included in this meta-analysis. The random-effects model was used to calculate the combined incidence rate and relative risk or risk difference.Results: This meta-analysis included nine longitudinal studies with 724 participants. We found that the mortality rates in the artesunate monotherapy group and the artesunate + adjuvant therapy group are similar (RD = −0.02, 95% confidence interval: −0.06–0.02). The incidence of adverse reactions in the artesunate monotherapy group and the artesunate + adjuvant therapy group was also similar.Conclusion: No significant differences in safety and efficacy were observed between the artesunate monotherapy group and the artesunate + adjuvant therapy group. Higher quality and rigorously designed randomized controlled studies are needed to validate our findings.

【 授权许可】

Unknown